cyclophosphamide
UK[ˌsaɪkləʊˈfɒsfəmaɪd]US[ˌsaɪkloʊˈfɑːsfəmaɪd]
n
A synthetic drug used in chemotherapy to treat various cancers and to suppress the immune system, for example before a bone marrow transplant.
Morpheme Breakdown
cyclo
phosph
amide
cyclo
ring
phosph
phosphorus
amide
chemical compound
Etymology
The name 'cyclophosphamide' is a modern scientific coinage that transparently describes its chemical structure. It combines 'cyclo-', indicating a ring-shaped molecular component, with 'phosph-', referencing the central phosphorus atom, and the suffix '-amide', which specifies the type of nitrogen-containing functional group. This nomenclature follows the systematic logic of organic chemistry, where morphemes are assembled like building blocks to convey precise molecular architecture. The word's entire history is embedded in this 20th-century construction, directly linking its literal, descriptive name to its function as a rationally designed pharmaceutical agent.
Analysis
Structure: cyclo (ring) + phosph (phosphorus) + amide (chemical compound)
- cyclo: From Greek kyklos (circle, ring). In chemistry, denotes a cyclic or ring-shaped structure.
- phosph: From Greek phōsphoros (light-bearing), via the element phosphorus. In chemistry, indicates the presence of phosphorus.
- amide: A chemical suffix from the root of ammonia, denoting a compound containing the -CONH₂ group.
Examples
The patient received a course of cyclophosphamide to treat her lymphoma.
Cyclophosphamide is often used in combination with other chemotherapeutic drugs.
A common side effect of cyclophosphamide is bone marrow suppression.